Structural genomics meets computational biology
نویسندگان
چکیده
منابع مشابه
Genomics and computational molecular biology.
There has been a dramatic increase in the number of completely sequenced bacterial genomes during the past two years as a result of the efforts both of public genome agencies and the pharmaceutical industry. The availability of completely sequenced genomes permits more systematic analyses of genes, evolution and genome function than was otherwise possible. Using computational methods - which ar...
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1 Hospital for Sick Children, Toronto, Canada, 2 Department of Biochemistry, University of Toronto, Toronto, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Canada, 4 EvoMRI Communications, Jena, Germany, 5 Open Knowledge Foundation Germany, Berlin, Germany, 6 Public Library of Science, Cambridge, United Kingdom, 7 Cell Networks, University of Heidelberg, Heidelberg,...
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Support vector machines and kernel methods are increasingly popular in genomics and computational biology, due to their good performance in real-world applications and strong modularity that makes them suitable to a wide range of problems, from the classification of tumors to the automatic annotation of proteins. Their ability to work in high dimension, to process non-vectorial data, and the na...
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Most of the genes of an organism are known from sequence, but most of the phenotypes are obscure. Thus, reverse genetics has become an important goal for many biologists. However, reverse-genetic methodologies are not similarly applicable to all organisms. In the general strategy for reverse genetics that we call TILLING (for Targeting Induced Local Lesions in Genomes), traditional chemical mut...
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The success of structural genomics initiatives requires the development and application of tools for structure analysis, prediction, and annotation. In this paper we review recent developments in these areas; specifically structure alignment, the detection of remote homologs and analogs, homology modeling and the use of structures to predict function. We also discuss various rationales for stru...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2006
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btl426